THE RESEARCH: AMPLIFYING ANTIOXIDANTS

Areas of Focus

Antioxidants are vital for life, constantly waging a microscopic war against free radicals and performing a balancing act that keeps the body in good health. Our fascination with these molecules, along with a passion for sound nutrition, accounts for our very name “AOX (shorthand for ‘antioxidant’) Biopharma.”

Drawing on decades of experience in microbiology, clinical nutrition, pharmacology, and rehabilitative health, our research seeks to elaborate on how powerful and versatile antioxidants can be, and how they can benefit the lives of humans and animals. We are constantly studying how to improve nutrient solubility so that they can absorb more quickly and completely, as well as how they can be formulated for topical application and beyond.

Thus far, our data-supported findings show immense promise in the areas of wound healing, skin health, and antibiotic resistance, and we see other potential in fields such as dietary supplementation and cancer therapy.

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Enhancing Absorption

Nutrient uptake is key to immune support. Much of our efforts seek to augment the bioavailability and delivery of nutrients and fat-soluble antioxidants (Vitamin D and E) into the body. We are even able to convert them into water-soluble forms that can fully penetrate the skin barrier and significantly affect wound healing.

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Improving Skin HealING

Maximizing the delivery of antioxidants and essential nutrients into the skin has a notable outcome on wound healing. One of our formulas demonstrates an improved inflammatory response, wound debridement, re-vascularization, and re-epithelialization in deep partial-thickness burns compared to the standard of care.¹

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Reducing Microbial Burden

Another crucial factor in wound healing is countering opportunistic pathogens. Our antimicrobial gel has proven to be effective at inhibiting and eliminating several major bacteria and fungi that cause infections,² especially Staphylococcus aureus⁴ and methicillin-resistant S. aureus (MRSA), for which we received a U.S. patent.³

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Breaking Biofilms

Bacterial biofilms are a major contributor to antibiotic resistance and a known threat to healthcare. Using Polymerase Chain Reaction (PCR) techniques, we’re examining the effects of our formulas on Staphylococcal biofilms⁶ and seeking novel methods of both preventing them from forming and penetrating those that are established.

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Filling Nutritional Gaps

Deficiencies in certain nutrients can affect various people, and one such nutrient is Vitamin D. The elderly and people with melanated skin or fat absorption issues often require higher doses of Vitamin D to support bone health. Another area of investigation is converting Vitamin D into a more soluble format that can be better absorbed.

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Solving Needs With Nutrition

The world of microbiology and cancer is an ever-evolving, ever-shifting puzzle. It is our goal to seek novel ways to prevent and treat health conditions - ranging from minor to life-threatening - with smart molecular nutrition that is not only proven to be effective, but safe as well.

Featured Publications

1) ARAG, an Antioxidant-Rich Gel, Shows Superiority to Mepilex Ag in the Treatment of Deep Partial Thickness Burns without Sacrificing Antimicrobial Efficiency

Brian Michael Cartwright, Sean James Fox, Mary Jane Underdown, William Andrew Clark, and Joseph Andrew Molnar; 2023

Published by: Antioxidants 2023, Volume 12, Issue 6, 1176. https://doi.org/10.3390/antiox12061176

2) Novel Antimicrobial Topical Gel That Exhibits Inhibitory Effectiveness Toward Common Microbes in Wound Infection (P19-007-19)

W. Andrew Clark, Rachel Ford, Lindsey Vance, Lexis Morley, Thomas Stovall, Leah McHale, Danny Raley, and Sean Fox; 2019

Published by: Current Developments in Nutrition, Volume 3, Issue Supplement 1, June 2019

U.S. Patent

3) Topical Gel Compositions for the Treatment of Staphylococcal Infections (U.S. Patent 10,912,759)

W. Andrew Clark, Ph.D, RD; February 2019

East Tennessee Health and Sciences Research Studies

4) A New All-Natural Wound Treatment Gel Shows Strong Inhibitory Activity Against Staphylococcus aureus and Other Wound Pathogens

Tasha Nelson, East Tennessee State University; May 2021

5) The Inhibitory Effects of an Antimicrobial Gel on the Staphylococcus Species

Mara Trinkle, East Tennessee State University; August 2020

6) The Inhibitory Effects of a Novel Gel on Staphylococcus Aureus Biofilms

Lindsey Vance, East Tennessee State University; May 2018

7) Burn Wound Bacteria Susceptibility to a Novel Antimicrobial Compound

Bo H. Marshall, East Tennessee State University; May 2017